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Bone metabolism is finely orchestrated by
2019-04-20
Bone metabolism is finely orchestrated by two types of antagonistic functional cells, bone-forming osteoblasts and bone-resorbing osteoclasts [6]. Bone tissue is continuously regenerated through a process “bone remodeling”, resulting in the maintenance of proper bone mass and quality [7]. The imbala
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br Conflict of interest statement br Acknowledgement
2019-04-19
Conflict of interest statement Acknowledgement We thank the constant support of nanomedicine research from the Ming Hsieh Institute for Research on Engineering-Medicine for Cancer. The authors certify that they have no affiliations with or involvement in any organization or entity with any fin
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br Discussion Metastatic RCC is
2019-04-19
Discussion Metastatic RCC is a fatal disease with survival often measured in months, rather than years. Surgery alone is the standard of care for patients who present with isolated renal disease at the time of diagnosis. However, approximately 1/3 of these patients will go on to develop clinicall
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In the univariate subgroup analysis the factors that predict
2019-04-19
In the univariate subgroup analysis, the factors that predicted reduced survival were increased age, significant mitral regurgitation (≥ grade 2), and creatinine level (Table 4). After multivariate analysis, (+)PES followed by ICD 7 8-dihydroxyflavone was a strong predictor of reduced mortality, al
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br Discussion PLSVC can be encountered for the first
2019-04-19
Discussion PLSVC can be encountered for the first time during electrophysiological procedures. It is the most common variation in the thoracic venous system and is estimated to be present in 0.3–0.5% of the general population and in 5–10% of patients with other congenital heart defects [3]. It ca
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Findings from the last major systematic
2019-04-19
Findings from the last major systematic review of the global prevalence of echocardiographic rheumatic integrin inhibitor disease showed that the highest calculated regional prevalence was in sub-Saharan Africa (5·7 cases per 1000 people), indigenous people in the Pacific islands, Australia, and New
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A substantial part of the value of setting goals
2019-04-18
A substantial part of the value of setting goals, targets, and indicators lies in the imperative to collect information for measurement and accountability —“what gets measured gets done”. The decision to exclude an indicator because it bcrp transporter is less established is diametrically opposed t
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Despite our best efforts the cause of SCD in
2019-04-18
Despite our best efforts, the cause of SCD in young individuals is sometimes not established; no cause is identified in up to 40% of cases. Importantly, whether a cause of death is established or not, the possibility of an underlying inherited cardiac disorder remains in many cases, including the po
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br Case A year old man was
2019-04-18
Case A 45-year-old man was referred for the management of sudden-onset tachycardia. He had experienced 3 episodes of palpitation attacks, lasting for a couple of hours each, during the last 6 months. A regular, wide QRS complex tachycardia (WCT) at 150beats/min with a prominent retrograde P wave
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Clinical history of patients with surface osteosarcoma depen
2019-04-18
Clinical history of patients with surface osteosarcoma depends on its grade of malignancy. In low grade lesions and especially in cPOS, symptoms are most often of prolonged duration [3]. However, in HGSO and DPOS—especially when the dedifferentiation is synchronous—clinical history is not distinguis
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We conducted a retrospective analysis to compare a
2019-04-18
We conducted a retrospective analysis to compare a BMD-alone strategy, versus BMD+FRAX® and BMD+FRAX®+TBS screening strategies. To our knowledge, this constitutes the first study to assess the relative contributions of FRAX® and TBS. In our cohort, FRAX®+BMD identified 9 (9%) additional patients at
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br Conclusions It is now clear
2019-04-18
Conclusions It is now clear that a number of CEP-37440 manufacturer are involved in inherited bradyarrhythmia. Recent genetic studies have demonstrated that inherited arrhythmia is attributable to many genes with diverse functions. While the precise underlying mechanisms remain to be elucidated;
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The exact incidences of amiodarone induced hyperthyroidism a
2019-04-18
The exact incidences of amiodarone-induced hyperthyroidism and amiodarone-induced hypothyroidism currently remain unknown; however, the reported frequencies of amiodarone-induced hyperthyroidism and amiodarone-induced hypothyroidism vary widely from 0.8% to 37.8% [7–16] and from 1% to 32% [13,17–20]
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br El giro dr stico o revelaci n
2019-04-18
El giro drástico o revelación en la voz enunciativa, produce una resignificación irónica de todo el cuento, que refuerza su carácter satírico. El tono de Florencio y sus afirmaciones contribuyen ionomycin dar vuelta al cuadro y presentarnos en el conjunto del texto una crítica ya no solo a los vic
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Si al hablar de realismo se alude en verdad a
2019-04-18
Si al hablar de “realismo” se alude en verdad focal adhesion kinase inhibitor un determinado tipo de relación entre literatura y realidad, es la pregunta acerca de las características de esta relación la que nos conduce nuevamente a las crónicas de Indias en la medida en que el siglo xvi en Occident
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