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Xie et al b reported
2022-05-04
Xie et al. (2009b) reported that the combination of diagnostic ultrasound impulses and cyclic RGD-bearing MBs targeted for GP IIb/IIIa resulted in the successful recovery of epicardial and microvascular blood flow in swine models with acute thrombotic occlusion. It is well known that the stability o
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Cortisol targets many organs and
2022-05-04
Cortisol targets many organs and tissues and has certain effects on metabolism, including promoting glycolysis. It can cross the blood CGS 35066 sale barrier and act centrally to regulate HPA axis activity by activating negative feedback mechanisms effectively, cortisol inhibits its own production
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Phylogenetic analysis of the secretin like hormones yields
2022-05-04
Phylogenetic analysis of the secretin-like hormones yields poorly supported trees due to the short length of their peptide sequences (Dores et al., 1996). However, phylogenetic analyses typically show that the secretin-like peptides encoded by the proglucagon (glucagon, GLP-1 and GLP-2) and GIP Lest
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br Results br Discussion Our studies highlight
2022-04-29
Results Discussion Our studies highlight MUFAs as key lipid modulators of both non-apoptotic and apoptotic cell death. Recent studies show that a more mesenchymal phenotype, de-differentiation, and acquired resistance to targeted inhibitors, can all promote a ferroptosis-sensitive cell state (
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br Results and discussion CATALYST software
2022-04-29
Results and discussion CATALYST software allows automatic pharmacophore construction by using a collection of molecules with activities ranging over a number of orders of magnitude. In addition, CATALYST pharmacophores (hypotheses) explain the variability of bioactivity with respect to the geomet
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Murine models of AML were used
2022-04-29
Murine models of AML were used to identify differentially expressed proteins following treatment with the EZH2 inhibitor, DZnep. Sandow and coworkers demonstrated that inhibition of EZH2 induces leukemia mg115 arrest through regulation of cyclin-dependent kinases and increased expression of p53, a c
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The effect of combined A
2022-04-29
The effect of combined A-192621 and PD 155080 treatment on the CHIR-99021 during endotoxin infusion is quite different compared to either drug used alone (Wanecek et al., 1999). After administration of both antagonists in combination, cardiac index increased to baseline values within 30 min, and wa
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Introduction Pneumocystis pneumonia PCP is a respiratory inv
2022-04-29
Introduction Pneumocystis pneumonia (PCP) is a respiratory invasive infection caused by Pneumocystis jirovecii, an ubiquitous fungus. It is transmitted by air and mostly infects immunocompromised patients. PCP is characterized by respiratory complaints of cough, dyspnea, but also tachycardia, low g
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The proposed contributory role of endogenous
2022-04-29
The proposed contributory role of endogenous histamine via activation of H1 receptor in the locomotor sensitization induced by caffeine was further ratified by H1 receptor antagonism during the induction phase and subsequently its effect on expression to locomotor sensitization induced by caffeine.
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The repurposing of well characterized and
2022-04-29
The repurposing of well-characterized and well-tolerated drugs in order to treat illnesses for which they were not originally intended has emerged as an attractive alternative to a long and costly process of drug development. Repositioning antihistaminergic ligands seems a promising idea given that
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Human epidermal growth factor receptor HER neu
2022-04-29
Human epidermal growth factor receptor 2 (HER2/neu, also known as CerbB-2, or ERBB-2) is a proto-oncogene located on chromosome 17q21, which encodes a transmembrane protein with tyrosine kinase activity, and belongs to the HER receptor family (EGFR, named also HER1, HER3, and HER4) [6]. HER2 is invo
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One of the possibilities of HO
2022-04-29
One of the possibilities of HO-1 targeting is gene therapy. So far, the majority of preclinical studies have focused on recombinant adeno-associated viral (rAAV) vectors as DNA carriers. They not only provide stable, long-term transgene expression in non-dividing ret inhibitor but also have very li
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Human immunodeficiency virus type HIV is
2022-04-29
Human immunodeficiency virus type 1 (HIV-1) is responsible for the amtb australia pandemic; notification is compulsory in Brazilian blood banks since 1988. From 1980 to 2016, the Brazilian MH reported 882,810 HIV/AIDS cases, with 52.3% in the southeast region. HIV/HCV co-infection has been associa
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Regarding the predictive value of the antidepressant
2022-04-29
Regarding the predictive value of the antidepressant effects of VP2.51 treatment (Fig. 4), different GSK-3 inhibitors produce decreased immobility in forced swim test (Du et al., 2010, Gould and Manji, 2004, Kaidanovich-Beilin et al., 2004, Rosa et al., 2008), with this being a widely used test to a
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br Conclusion br Acknowledgments br Introduction The gyloxal
2022-04-26
Conclusion Acknowledgments Introduction The gyloxalase pathway is a well-conserved antioxidant defense system found in all cells of the body [1], [2], [3], [4]. The glyoxalase pathway facilitates the neutralization of highly reactive and oxidizing dicarbonyl molecules, with methylglyoxal (M
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