• br Introduction Soluble guanylyl cyclase GC maintains vascul

  2021-10-21

  

  Introduction Soluble guanylyl cyclase (GC-1) maintains vascular function through the NO/GC-1/cGMP pathway [1,2] by catalyzing the conversion of GTP into cGMP (Fig. 1). The GC-1 heme prosthetic group binds NO with picomolar affinity, resulting in a 100- to 200-fold increase in catalytic activity.

• The intracellular signaling that mediates the adipogenesis

  2021-10-20

  

  The intracellular signaling that mediates the adipogenesis induced by GPR120 still remains largely unknown. In the present study we showed that TUG-891 induced the activation of [Ca2+]i and ERK1/2 signaling in 3T3-L1 cells. Moreover, incubation of TUG-891 combined with BAPTA-AM or U0126 abolished TU

• br Introduction Fructose bisphosphatase FBPase EC catalyses

  2021-10-20

  

  Introduction Fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11) catalyses the irreversible reaction of hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate [1]. Genetic and kinetic studies so far have demonstrated that at least two distinct isoenzymes of FBPase e

• The minimal segment of the SIM appears to be

  2021-10-20

  

  The minimal segment of the SIM appears to be a core of SKF38393 HCl australia residues, which frequently matches the consensus sequences ΨΨΨΨ, ΨxΨΨ, or ΨΨxΨ (where Ψ is V, I, or L and x is typically D, E, S, or T) [29,31,32]. In a subset of SIMs, this hydrophobic core is flanked by serine residues

• The neurotransmitter histamine plays a key role in the

  2021-10-20

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in azd2171 australia histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's disease

• br Introduction Circulating tumor cells CTCs are cancer cell

  2021-10-20

  

  Introduction Circulating tumor rxr receptor (CTCs) are cancer cells that have invaded blood vessels or lymphatics and are carried around the body by the blood. CTCs constitute potential seeds for metastasis because they can reach and implant into distant organs. The clinical importance of CTCs w

• Overall more males were HCV

  2021-10-20

  

  Overall, more males were HCV mono- and co-infected, though there was no significant age difference among groups and between men and women (all p>0.05). Almost all patients included in this study were over 40 years, in line with the period in which no HCV screening was performed in Brazilian blood b

• Similar to Rac Cdc and RhoA expression of Rnd

  2021-10-20

  

  Similar to Rac1, Cdc42, and RhoA, expression of Rnd3 is also increased under hypoxic conditions, involving Hif1α mediated transcriptional activity. Here, downregulation of Rnd3 abolishes hypoxia-induced cell migration via a mechanism involving the chemokine receptor C-X-C motif chemokine receptor 4

• br Materials and methods br Results br Discussion An

  2021-10-20

  

  Materials and methods Results Discussion An HMC is a blinding type of cataract frequently observed in Asian countries due to the appallingly high incidence of high myopia in those areas [4], [5] and typically features earlier onset and more rapid progression of nuclear cataract [1], [2]. Th

• br Materials and methods br Results br Discussion Although t

  2021-10-20

  

  Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic px12 is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the phenoty

• The treatment target which aims at diagnosing

  2021-10-20

  

  The “90-90-90 treatment target” which aims at diagnosing 90% of HIV-infected individuals, treating 90% of those diagnosed and achieve viral suppression for 90% of treated individuals, is a key strategy to achieve one of the sustainable development goals (SDG) of ending AIDS as a public health threat

• YM178 No compounds in this series showed any

  2021-10-20

  

  No compounds in this series showed any appreciable activity at GlyT2 and can thus be considered GlyT1-selective. For the GlyT2 IC was >20μM. To determine CNS penetration of -(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides, select compounds were evaluated in a cassette CNS exposure screen in ma

• Oxidative stress results from the

  2021-10-20

  

  Oxidative stress results from the disequilibrium between levels of prooxidant molecules produced and the ability of a biological system to detoxify and neutralize the reactive molecules [14]. OS is a chronic, self-perpetuating state of damage to cells and increased inflammation resulting from the co

• The previous studies focused on the regulation of GK activit

  2021-10-19

  

  The previous studies focused on the regulation of GK activity by nutrients directly or nutritional hormones (Panserat et al., 2014), there was still a lack of studies paid attention to GK both in activity level and transcriptional level. Besides, the GK regulation by dietary CPI-203 has been definit

• br Materials and methods br

  2021-10-19

  

  Materials and methods Results Discussion In this study, we identified a novel AMP scolopendrasin X from Scolopendra subspinipes mutilans through genome analysis. Scolopendrasin X stimulated neutrophil activity, resulting in calcium increase, chemotactic migration, and superoxide anion produ

16001 records 590/1067 page Previous Next First page 上5页 586587588589590 下5页 Last page