• br Dynamic Localization of Hippo Pathway Components The obse

  2021-10-08

  

  Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i

• Importantly recent in vivo results demonstrated

  2021-10-08

  

  Importantly, recent in vivo results demonstrated that combining an HDACi and a IKK inhibitor significantly reduced ovarian tumor growth compared with either inhibitor alone [26]. The slowest tumor growth in the HDACi/IKK inhibition combination group was associated with the lowest CXCL8 tumor and pla

• br Conclusion br Conflict of interest br References and

  2021-10-08

  

  Conclusion Conflict of interest References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Free fatty acids (FFAs) are essential nutrients that contribute to various cellular functio

• To date no studies have demonstrated

  2021-10-08

  

  To date, no studies have demonstrated any effect of obesity or inflammation on GPR109A expression in adipose tissue. Our findings demonstrate that HFD-induced obesity decreases adipose tissue GPR109A gene expression. Contradictory to our findings in adipose tissue in vivo, Digby et al. report that e

• Several studies have found that GPR

  2021-10-08

  

  Several studies have found that GPR55 possesses a distinct pharmacology from that of CB1 and CB2, and that only certain cannabinoids act at this receptor. In transfected tankyrase expressing hGPR55, out of more than 20 synthetic and endogenous cannabinoids evaluated, only 2 compounds, SR141716A (Ri

• br Materials and methods br Results

  2021-10-08

  

  Materials and methods Results Discussion and conclusions Our data demonstrate that native and 2-OMe-LPC analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells. LPC 18:1 was the first proposed endogenous ligand for GPR119 [1], however natural LPC has limited

• br Conclusion br Conflict of interest statement br Reference

  2021-10-08

  

  Conclusion Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as Introduction Over the past decade, more than a hundred new biopharmaceutical products have been approved and market

• Iohexol br Introduction The alternative splicing of

  2021-10-08

  

  Introduction The alternative splicing of pre-mRNA is essential for generating multiple matured mRNAs from a single gene by selectively removing introns. Neural Iohexol show many examples of regulated alternative splicing events, which produce structural changes in proteins important for the deve

• br Material and methods br Results

  2021-10-08

  

  Material and methods Results Discussion Functional characterization of naturally occurring GCK mutations in patients with impaired glucose homeostasis has widened our knowledge of the catalytic and regulatory mechanisms of this enzyme [3]. In this work, we have biochemically characterized a

• DBeQ Sexual size dimorphism has been

  2021-10-08

  

  Sexual size dimorphism has been observed in European eel and half-smooth tongue sole (Cynoglossus semilaevis), as females have a faster growth rate than males, (Degani, G., et al., 2003, Ma, Q., et al., 2012). Ma et al. 2011 reported that the mRNA level of GH was higher in the pituitary gland of bot

• We found that silymarin induced more improvement of

  2021-10-07

  

  We found that silymarin induced more improvement of renal functions compared to Rvs. Our results were in agreement with previous studies. The effect of silymarin has been tested in alloxan-induced diabetes mellitus models in rats. Alloxan produces reactive oxygen species which injure renal tissue. S

• Macroautophagy hereafter referred to as autophagy depends on

  2021-10-07

  

  Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl

• To meet the requirement of ferroptosis

  2021-10-07

  

  To meet the requirement of ferroptosis-based therapy, a couple of small molecule drugs and nanomaterials were introduced to the design of ferroptosis inducers, separately. As we know, iron is a key regulator of ferroptosis. When small molecule drugs are employed to induce ferroptosis, the endogenous

• Consistent with our result Camacho Barquero and

  2021-10-07

  

  Consistent with our result, Camacho-Barquero and coworkers showed that curcumin reduced phospho-P38 MAPK. P-38 MAPK is a key effector of several downstream factors that eventually modulate the homing of monocytic cells during the onset of intestine inflammation (Camacho-Barquero et al., 2007). Along

• Management of HIV treatment with HIV PIs

  2021-10-07

  

  Management of HIV-1 treatment with HIV PIs can be complicated due to wide inter-patient variability in gdc-0980 receptor levels. In certain scenarios, therapeutic drug monitoring (TDM) has been recommended as a useful approach to individualize therapy for HIV-infected patients [[9], [10], [11], [12]

15916 records 593/1062 page Previous Next First page 上5页 591592593594595 下5页 Last page