• Some members from the AAAP family namely

  2024-07-11

  

  Some members from the AAAP family, namely the AUX1 and the LAX proteins, transport auxin instead of amino acids [48]. While there is some structural relationship between IAA and Trp, the substrate recognition characteristics seem different for these proteins: the auxins do not have any amino group o

• Aberrant lipid levels are associated with various disorders

  2024-07-11

  

  Aberrant lipid levels are associated with various disorders, including vascular diseases and diabetes. Furthermore, important events support the idea that lipids, especially cholesterol and its derivatives, have a fundamental role in the physiopathology of AD. The chloroquine phosphate is rich in c

• jc1 Interestingly intermittent high doses of AKT inhibitors

  2024-07-10

  

  Interestingly, intermittent high doses of AKT inhibitors have been shown to be a more effective strategy both clinically and pre-clinically. High doses appear to be required for induction of apoptosis and intermittent schedules overcome the low therapeutic index of these compounds. This is particula

• br Theoretical mechanism of ABCA activity in LE LY

  2024-07-10

  

  Theoretical mechanism of ABCA2 activity in LE/LY in modulation of cholesterol trafficking It is important to confirm that ABCA2 is a lipid transporter and identify the substrates that are mechanistic in its cholesterol sequestering activity. We hypothesize that ABCA2 modulates cholesterol sequest

• Introduction An association of elevated branched chain

  2024-07-10

  

  Introduction An association of elevated branched-chain epz (BCAA—Leu, Val, Ile) with obesity and insulin resistance was first reported nearly 50 years ago (Felig et al., 1969). With the advent of metabolomics technologies, it has since become apparent that the association of BCAA and related metab

• br Results br Discussion br Conclusions In summary this stud

  2024-07-10

  

  Results Discussion Conclusions In summary, this study provides novel report of pericardial adipose aromatase expression – in both human and rodent. We show that aromatase expression is remarkably upregulated with aging (Fig. 1C), and that total aromatase Potassium Canrenoate conversion capa

• br Polymorphic variation ERAP is

  2024-07-09

  

  Polymorphic variation ERAP1 is polymorphic and several single nucleotide polymorphisms (SNPs) in its gene that encode amino Reserpine hydrochloride changes have been associated with predisposition to a variety of diseases, ranging from viral infections to cancer and autoimmunity (Alvarez-Navarro

• Several enzymes in serine and glycine metabolism have

  2024-07-09

  

  Several enzymes in serine and glycine metabolism have been proposed as biomarkers for cancer stage and prognosis. Phosphoglycerate dehydrogenase (PHGDH), phosphoserine phosphatase (PSPH), and serine hydroxymethyltransferase (SHMT) levels are high in TNBC and low in luminal-A breast cancers (Kim et a

• On the other hand it is important to note that

  2024-07-09

  

  On the other hand, it is important to note that FR is different from the regulation of daily/circadian rhythms [44]. Based on models of physical systems [45], [46], it has been hypothesized that fractal physiological fluctuations reflect a network of elaborate regulatory processes interacting across

• Decrease in soluble protein content in

  2024-07-09

  

  Decrease in soluble protein content in diabetic lenses compared with those in control lenses in present study could be due to leakage of proteins and insolubilization. T. purpurea treatment could increase the levels of soluble proteins in diabetic lenses may be by preventing cross-linking/aggregatio

• br Role of OCT in histamine clearance Histamine

  2024-07-09

  

  Role of OCT3 in histamine clearance Histamine is a powerful neuromodulator, as well as a regulator of immune processes and vascular tone in the central nervous system (Gross, 1981; Haas et al., 2008; Jutel et al., 2006). In contrast to 5-HT and the catecholamines, a high-affinity transporter for

• Rising depolarization was observed during and decaying depol

  2024-07-09

  

  Rising depolarization was observed during and decaying depolarization after the photostimulation (Fig. 1D). The slow decrease of the firing rate after photostimulation is also a remarkable characteristic of the striatal neuron (Figs. 1E, 2 and 3), since the cortex pyramidal neurons (data not shown)

• We also demonstrate that PACAP

  2024-07-09

  

  We also demonstrate that PACAP treatment dose-dependently disrupts performance in the 5CSRTT, suggestive of attentional deficits, another core feature of mood and anxiety disorders. Treatment with PACAP (.5–1.0 µg) decreased the percentage of correct responses, increased the percentage of trials in

• br Actin at presynapses br

  2024-07-09

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal AT9283 is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb these str

• ER 27319 maleate br Conclusion There have been multiple clin

  2024-07-09

  

  Conclusion There have been multiple clinical trials and pre-clinical studies that have tested the utility of 5ARIs in treating prostate disease, as summarized in Fig. 1. Inhibiting androgen action through the use of finasteride and dutasteride has been established as a valuable resource for physi

15330 records 76/1022 page Previous Next First page 上5页 7677787980 下5页 Last page