• Recent studies have analyzed the miRNA profile of

  2019-06-01

  

  Recent studies have analyzed the miRNA profile of serum and bile samples from patients with PSC and patients with CCA complicating PSC. Overall, the miRNA expression of all analyzed miRNAs from both patients with PSC and patients with CCA complicating PSC was significantly higher compared with heal

• br Discovery of S PR as a CBA

  2019-06-01

  

  Discovery of S1PR2 as a CBA sensor in the liver Early studies reported that activation of the ERK1/2 and AKT signaling pathways by CBAs was PTX-sensitive, suggesting a role for a Gαi-linked GPCR. To identify which GPCR activates the ERK1/2 and AKT signaling pathways, the cDNAs encoding more than

• Dyslipidemia is characterized by increased total cholesterol

  2019-05-31

  

  Dyslipidemia is characterized by increased total cholesterol, LDL-C, and triglyceride levels, and decreased HDL-C levels. However, the association of ApoA1 polymorphism with serum HDL-C level remains controversial. The polymorphisms of ApoA1+84 TC, but not MspI, are associated with serum HDL-C. The

• br Conflict of interest br Authors contributions br Acknowle

  2019-05-31

  

  Conflict of interest Authors’ contributions Acknowledgements Introduction Aromatase-Inhibitors (AIs) are commonly used in the treatment of post-menopausal women with a history of hormone receptor-positive breast carcinoma, and have been shown to decrease bone mineral density (BMD) and in

• wee1 inhibitor Si al hablar de realismo

  2019-05-31

  

  Si al hablar de “realismo” se alude en verdad wee1 inhibitor un determinado tipo de relación entre literatura y realidad, es la pregunta acerca de las características de esta relación la que nos conduce nuevamente a las crónicas de Indias en la medida en que el siglo xvi en Occidente es un momento e

• br Introduction Bone marrow fibrosis

  2019-05-31

  

  Introduction Bone marrow fibrosis is known to occur in several neoplastic and non-neoplastic conditions. Among neoplastic conditions such as acute leukemia, it is most often seen with acute megakaryoblastic leukemia [1]. Acute promyelocytic leukemia (APL) presenting with marrow fibrosis is a rar

• We report a case of DCML deficiency and MDS

  2019-05-31

  

  We report a case of DCML deficiency and MDS in a patient with GATA2 mutation who successfully underwent allogeneic stem cell transplantation. Case report At presentation, she had adapted to a hemoglobin level of 79g/l and had only occasional discrete symptoms of her anemia, as fatigue, other con

• A year old man was hospitalized following a first

  2019-05-31

  

  A 36-year-old man was hospitalized following a first syncope attack while awake at night. No history of sudden death was reported in his family. On arrival, his consciousness was clear and his vital signs were stable. An electrocardiogram (ECG) showed sinus rhythm with ST-segment elevations and J wa

• Introduction Dilated phase hypertrophic cardiomyopathy DHCM

  2019-05-31

  

  Introduction Dilated-phase hypertrophic cardiomyopathy (DHCM) is a rare subset of hypertrophic cardiomyopathy (HCM) [1]. Data available on sustained monomorphic ventricular tachycardia (SMVT) associated with DHCM is scarce. We report a rare case of SMVT caused by a large epicardial scar related to

• En diversos lugares de M xico como

  2019-05-31

  

  En diversos lugares de México, como en Guerrero, el Valle del Mezquital, la región de Actopan, etc., según confirman las publicaciones del Instituto Nacional de Antropología e Historia de la ciudad de México, la creencia de que los huesos de los antepasados se convierten en piedras con propiedades e

• HZ-1157 Extra amente el narrador de Rubem Fonseca omite cual

  2019-05-30

  

  Extrañamente, el narrador de Rubem Fonseca omite cualquier alusión HZ-1157 esta segunda carta, quizá considerando él mismo que no es auténtica, mientras que la primera es citada de una forma premonitoria, al igual que las palabras de Papá Miguel: “Deixo à sanha dos meus inimigos o legado da minha mo

• br Indigenous communities experience some of the highest rat

  2019-05-30

  

  Indigenous communities experience some of the highest rates of suicide globally, especially among young people. This worrying epidemic has already been shown in Inuit communities of North America and Greenland and the Amazonian groups of Guyana, but recently has been shown to extend to Australian

• Myeloid sarcoma can be observed as a

  2019-05-30

  

  Myeloid sarcoma can be observed as a de novo malignancy (without leukemic presentation in peripheral blood and bone marrow), during the course of acute myeloid leukemia (AML), affecting 2.5–9% of all AML patients, myelodysplastic syndromes (MDS) or myeloproliferative neoplasms (MPNs, both chronic my

• Fourth social rehabilitation and reintegration of

  2019-05-30

  

  Fourth, social rehabilitation and reintegration of patients with fistula along with ibmx sensitisation (to prevent the occurrence of fistula, as well as to mitigate against stigmatisation of fistula survivors) will be crucial to eliminate obstetric fistula. Many women might not seek surgical care f

• Different ideas however emerged in the s and s

  2019-05-30

  

  Different ideas, however, emerged in the 1960s and 1970s in the minds of computational biologists interested in the theory of wave propagation in excitable media. Based on chemical [17] and numerical experiments, [18] scientists in the Soviet Union and the USA began to suggest that fibrillation was

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