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Introduction Alzheimer s disease AD is
2024-05-11
Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prot
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The metabolism of amino acids into volatile
2024-05-11
The metabolism of amino acids into volatile aldehydes involves both decarboxylation and deamination steps. The order of these reactions and the enzymes performing the catalysis differ among plants [13]. In tomato fruit the conversion of L-Phe to 2-phenylethanal is catalyzed by two enzymatic steps, i
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In conclusion our study would seem to
2024-05-11
In conclusion, our study would seem to indicate that a hydrophilic microenvironment, which is suitable to accommodate highly hydrophilic molecules with steric hindrance such as aldose hemiacetals, allows the enzyme modulation by one of its most important physiopathological substrates. It is difficul
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formyl Drug resistance development often involves structural
2024-05-10
Drug resistance development often involves structurally un-related drugs and, specifically both conventional and targeted agents. IGROV-1/Pt1 formyl are characterized by resistance to cisplatin and reduced sensitivity to inhibitors of EGF-R and MEK, the up-stream activator of ERK1/2, associated with
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br Regulation of V ATPase assembly in
2024-05-10
Regulation of V-ATPase assembly in response to changes in amino AR 231453 synthesis levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis a
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By contrast with a plenty of our understanding on
2024-05-10
By rgd peptide with a plenty of our understanding on arginine metabolism in animals and higher plants, very little thus far is known on the specific function of arginase that acts as a key control point for keeping arginine balance in edible mushrooms and neither for its physiological role in postha
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CORT induced hippocampal damage has been implicated in depre
2024-05-10
CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective
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exportin HMGN proteins are subject to extensive
2024-05-10
HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to exportin and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in [175]). The hi
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r78 br Diabetic retinopathy Diabetic retinopathy is a severe
2024-05-10
Diabetic retinopathy Diabetic retinopathy is a severe sight-threatening complication associated with diabetes mellitus. It is one of the most common causes of preventable blindness in the world. The risk of developing microvascular diabetic complications increases in diabetic patients with an inc
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ZD6474 mg Various compounds have been designed to inhibit al
2024-05-10
Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic ZD6474 mg moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a pot
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br Methods br Results br Discussion First the cells
2024-05-09
Methods Results Discussion First, the 848 isolated from non-PD TA tissue and PD plaque tissue were characterized. The results showed that both cell groups were positive for vimentin and negative for desmin suggesting that these cells were fibroblasts. It was also observed that treatment wi
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br The role of AMPK
2024-05-09
The role of AMPK beyond LY2606368 synthesis homeostasis: regulating metabolism AMPK plays a major role in glucose homeostasis by modulating glucose transport in peripheral tissues [20]. Skeletal muscle, one of the main peripheral tissues involved in glucose uptake and disposal, expresses glucose
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br Funding br Introduction The interest in the
2024-05-09
Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a
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Introduction Dementia is a common disease in the elderly and
2024-05-09
Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (
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tetracycline hcl br Materials and methods br Results br
2024-05-09
Materials and methods Results Discussion Prostate cancer represents an ideal candidate for chemoprevention because of its high incidence and long latency to clinically significant disease [17]. The precancerous lesion PIN may also be a suitable target for ablation in chemoprevention strateg