• We have previously shown that the human gonadotropins

  2024-06-17

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor 4-iodo-SAHA (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight i

• br Results br Discussion Today

  2024-06-17

  

  Results Discussion Today, enzymes play important roles in various fields. A good assay for enzyme activity is of great value, especially when it has good specificity, sensitivity, reproducibility and economy. ADK is the first identified enzyme in the metabolic pathway of adenosine salvage [15,

• energy metabolism br Actin at presynapses br Conclusion Than

  2024-06-17

  

  Actin at presynapses Conclusion Thanks to the recent discovery of rings, hotspots and trails, axonal energy metabolism is back in the spotlight. These are exiting times for neuronal cell biologists armed with constantly improving labeling and imaging techniques to observe, quantify and perturb

• Apoptosis or programmed cell death

  2024-06-17

  

  Apoptosis or programmed cell death is a function of biochemical mechanisms, which are energy-dependent. It is considered to be a vital component of many processes such as normal cell cycle, immune mechanism, atrophy, embryonic development and toxin-induced cell death (Elmore, 2007). In addition, apo

• In an AP scenario several inflammatory mediators

  2024-06-17

  

  In an AP scenario, several inflammatory mediators are produced locally to orchestrate an immune response. Eicosanoids are among those molecules and represent a class of lipid mediators synthesized from arachidonic 5416 through the action of cyclooxygenases or lipoxygenases to generate prostaglandin

• br Conclusion br Conflicts of interest br Introduction RNA i

  2024-06-17

  

  Conclusion Conflicts of interest Introduction RNA interference is a specific post-transcriptional gene silencing mechanism within a cell via the transfection of microRNAs (miRNA), exogenous small interfering RNAs (siRNA) or small hairpin RNAs (shRNA) [1–3]. Transfection of shRNA can be done

• Previously several genes such as

  2024-06-17

  

  Previously, several genes such as cytokine (Lyu and Park, 2007), cell motility-associated genes (Schotterl et al., 2017), transforming growth factor-β (TGF-β), TGF-β receptor II which is a cell surface receptor with serine/threonine kinase activity (Jiang et al., 2014, Schotterl et al., 2017), cell

• br Materials and methods br Results br

  2024-06-17

  

  Materials and methods Results Discussion We have developed a high-throughput functional genomic screen that allows the identification of genes that confer drug resistance. Several factors have been identified which must be taken into account to develop a reliable screen. In particular, cons

• Based on currently available knowledge autophagy supports ad

  2024-06-17

  

  Based on currently available knowledge, autophagy supports adipocytes development and differentiation. In animals with specific skeletal muscle Swainsonine of Atg7, reduced adipogenesis was shown. In rodents, autophagy was decreased in adipose tissue of animals fed with high-fat diet (HFD). In contr

• Loss of virulence in ACL mutants may

  2024-06-17

  

  Loss of virulence in ACL mutants may be caused by defect in vegetative growth and conidial germination, and reduced trichothecene production. However, supplement of potassium acetate restored the defects in germination rate and vegetative growth, but not virulence in wheat heads (Table 2, Fig. 2B),

• The canonical binding sites to which or contribute

  2024-06-17

  

  The canonical Licarbazepine to which α2, α3, or α5 contribute are highly similar. Therefore, differences in ligand affinity will not be large even if a ligand makes optimal use of the small differences in the pockets. As a possible alternative approach to achieve separation of compound effects, lig

• Thirdly and finally multiple studies

  2024-06-17

  

  Thirdly and finally, multiple studies have analyzed the activation of neurons in the auditory telencephalic areas of songbirds in response to various auditory stimuli. Neuronal activation was identified by the increased expression of immediate early genes such as fos or ZENK (also know as zif-268, e

• Mechanistically it was soon realized that

  2024-06-17

  

  Mechanistically, it was soon realized that in undead cells, Dronc promotes the activation of Jun-N-terminal kinase (JNK) signaling as the major inducer of AiP [25], [28] (Fig. 2B,C). However, it has been unknown for a long time how active Dronc promotes JNK signaling. Recently, it was reported that

• Echinocandin resistance is systematically associated with po

  2024-06-17

  

  Echinocandin resistance is systematically associated with point mutations in either FSK1 or FSK2 genes [7], [104]. These mutations are located in two different not spot regions of these genes named HS1 and HS2. Hot spot mutations have been reported in C. albicans, C. glabrata, C. tropicalis, C. krus

• Sildenafil Citrate Thalidomide is now a well known antiangio

  2024-06-17

  

  Thalidomide is now a well known antiangiogenic agent. This property of thalidomide is being extensively researched upon, for its significant utility in the treatment of various malignant tumors. Studies show that thalidomide efficaciously inhibits various pro-angiogenic factors such as tumor necrosi

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