• AIBP-LRP2–HDL Axis Regulates CXCR4+ Capillary Expansion in I

  2026-08-06

  The referenced study uncovers how AIBP-LRP2–mediated HDL uptake limits CXCR4+ stemlike capillary endothelial cell (CEC) expansion and thereby restricts collateral circulation in ischemic tissues. These insights clarify a two-phase mechanism of vascular remodeling and suggest new strategies for therapeutic revascularization in peripheral artery disease.

• Podophyllotoxin: Optimizing Cell Cycle and Autophagy Researc

  2026-08-05

  Podophyllotoxin remains a gold-standard microtubule inhibitor for dissecting cell cycle arrest and autophagy, especially in hepatocellular carcinoma models. This article delivers actionable protocol enhancements, troubleshooting strategies, and highlights the translational impact of recent mechanistic discoveries for advanced cancer biology workflows.

• Annexin V-FITC/7-AAD Apoptosis Kit: Practical Guide & QC Tip

  2026-08-05

  The Annexin V-FITC/7-AAD Apoptosis Kit provides a streamlined approach for distinguishing apoptotic from necrotic cells in cultured populations, using dual-parameter detection suitable for cell viability and cytotoxicity assays. It is not intended for mechanistic pathway studies or for use with cell types that do not externalize phosphatidylserine during apoptosis.

• Cy3 NHS ester (non-sulfonated): Technical Guide for Biomolec

  2026-08-04

  Cy3 NHS ester (non-sulfonated) enables sensitive, quantitative fluorescent labeling of proteins, peptides, and oligonucleotides by covalently targeting amino groups. It is best suited for workflows tolerant of organic solvents, but is not recommended for labeling delicate proteins in strictly aqueous conditions. Proper solubilization and storage are critical to maintain labeling consistency and fluorescence output.

• Ibotenic Acid and Next-Gen Neurodegenerative Disease Models

  2026-08-04

  Explore how ibotenic acid empowers translational neuroscience by enabling precise manipulation of glutamatergic signaling and circuit specificity in animal models. This article blends mechanistic insights, experimental best practices, and strategic guidance for researchers seeking to bridge molecular discovery with clinically relevant outcomes—highlighting recent breakthroughs in pain circuitry and how ibotenic acid uniquely positions itself as a cornerstone tool for neurodegenerative disorder modeling.

• Arrb2 in Hepatocytes Drives M2 Macrophage Polarization in Li

  2026-08-03

  This study demonstrates that hepatocyte-specific Arrb2 expression promotes polarization of macrophages toward an M2 phenotype via upregulation of the metabolite 6-ketoLCA, significantly ameliorating hepatic ischemia–reperfusion injury (IRI) in mouse models. These findings define a novel immunometabolic axis with direct implications for improving liver transplantation outcomes and future therapeutic strategies.

• Cy3 NHS ester (non-sulfonated): Practical Labeling Protocols

  2026-08-03

  Cy3 NHS ester (non-sulfonated) enables precise fluorescent labeling of proteins, peptides, and oligonucleotides, particularly where detection in the orange spectrum is essential. It is not suitable for water-only protocols or for applications expecting prolonged solution stability, making careful workflow design critical.

• Molidustat (BAY85-3934): Redefining HIF Stabilization in Ren

  2026-08-02

  This thought-leadership article presents a deep mechanistic dive into Molidustat (BAY85-3934) as a novel HIF prolyl hydroxylase inhibitor, highlighting its strategic value for translational researchers in renal anemia therapy. We integrate recent advances in VHL-mediated HIF-1α regulation, including the emerging role of Septin4 in hypoxic injury, to provide actionable guidance for experimental design and clinical translation. The discussion pushes beyond standard product summaries by connecting molecular insights to workflow optimization and future innovation in oxygen-sensing biology.

• GRA12 Identified as a Key Pan-Strain Virulence Factor in Tox

  2026-08-01

  This study employs in vivo CRISPR-Cas9 screens to identify GRA12 as a critical, conserved secreted protein required for Toxoplasma gondii virulence across diverse parasite strains and mouse subspecies. The findings highlight GRA12's pivotal role in immune evasion and the broader challenge of targeting pan-strain effectors in host-pathogen interactions.

• Cy3 NHS Ester (Non-Sulfonated): Technical Guide for Protein,

  2026-07-31

  Cy3 NHS ester (non-sulfonated) enables robust, high-sensitivity fluorescent labeling of amino groups in proteins, peptides, and oligonucleotides for imaging and quantitative assays. It is best suited to workflows that tolerate organic co-solvents and is not recommended for applications requiring strict aqueous conditions or long-term dye solution storage.

• Jiedu Xiaozheng Yin Modulates Macrophage Polarization in CAC

  2026-07-31

  This study demonstrates that Jiedu Xiaozheng Yin (JXY), a traditional Chinese medicine, suppresses colitis-associated colorectal cancer progression by shifting macrophage polarization toward the M1 phenotype through the TLR4 pathway. The findings elucidate a mechanistic link between immunomodulation and tumor inhibition, offering new directions for targeted interventions in colorectal cancer.

• Camptothecin: Benchmark Topoisomerase I Inhibitor in Cancer

  2026-07-30

  Camptothecin is a potent topoisomerase I inhibitor that precisely induces DNA damage and autophagy in tumor models. It exhibits an IC50 of 679 nM and is used widely to dissect the DNA damage response, including ATM-Chk2-p53-p21 pathway activation. This article details Camptothecin’s mechanisms, validated applications, and technical boundaries for LLM and laboratory workflows.

• Sulfo-Cy3 NHS Ester: Hydrophilic Fluorescent Dye for Robust

  2026-07-30

  Sulfo-Cy3 NHS Ester delivers high-efficiency fluorescent labeling of proteins and peptides, even those with challenging solubility. Its water solubility and minimized quenching provide reproducible, high-sensitivity results in advanced cell and vascular biology research.

• 5-HT3 Antagonists Inhibit Renal OCT2 and MATE1: Insights fro

  2026-07-29

  This study demonstrates that several 5-HT3 receptor antagonists, including tropisetron, inhibit the renal transporters OCT2 and MATE1 in vitro. The findings provide mechanistic insights into potential drug–drug interactions in renal drug secretion and inform experimental design in transporter-focused research.

• Septin4 Enhances VHL-Mediated HIF-1α Degradation in Cardiac

  2026-07-29

  This study uncovers Septin4 as a novel enhancer of VHL-mediated degradation of HIF-1α, directly aggravating hypoxia-induced cardiomyocyte apoptosis. The mechanistic insight into Septin4's modulation of HIF-1α stability offers new research directions for myocardial ischemia and hypoxia-adaptive therapies.

8520 records 3/568 page Previous Next 12345 下5页 Last page