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Our analysis has devoted limited attention to the
2024-09-27

Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost
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In an effort to determine if one
2024-09-27

In an effort to determine if one 5ARI was more effective than the other, the Enlarged Prostate International Comparator Study (EPICS) [17] compared treatment with finasteride and dutasteride in 1630 men over the age of 50 and concluded that after one year of treatment, both groups had statistically
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This study does have several limitations mainly related
2024-09-27

This study does have several limitations, mainly related to the DMSO vehicle. While DMSO is a known anti-inflammatory mediator,5, 12 it has been shown to upregulate ALOX5, which was not seen in this study (as we are likely underpowered to detect this difference). A manifestation of this anti-inflamm
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On the contrary evidence also suggests
2024-09-27

On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer dpp-4 inhibitors require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as a friend providing a
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Recent studies showed that the increased expression of Auror
2024-09-27

Recent studies showed that the increased expression of Aurora B kinase directly proportional to the tumor invasion and metastasis [61]. The Aurora B kinase regulates the PI2K/Akt signaling pathway has a significant role in tumor invasion and metastasis that leads to phosphorylation of GSK3β on ser 9
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The activity of an enzyme may be regulated allosterically as
2024-09-27

The activity of an enzyme may be regulated allosterically as well as transcriptionally. We have consistently studied REMS deprivation (REMSD) associated NA mediated allosteric regulation of Na-K ATPase activity in neurons and glia in vivo and in vitro (Amar and Mallick, 2015; Amar et al., 2016; Bask
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A disruption of lung barrier function caused by
2024-09-27

A disruption of lung barrier function caused by PM2.5 has been observed in our experiments; however the underlying mechanism has not been investigated. Zhao et al. (2018) reported that PM2.5 down-regulated the expression levels of tight junction (TJ) proteins and resulted in nasal epithelial barrier
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Finally the comparison between data obtained by
2024-09-27

Finally, the comparison between data obtained by antioxidant assays in in vitro cultured cells [11], [12] and in liposomes has disclosed the possibility to choose more confidently “the better phenolipid” of a series of fatty acids esters antioxidant derivatives. Looking at the physical parameters th
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In addition to peroxyl radicals
2024-09-27

In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as
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Serum concentrations of acute phase proteins APP and
2024-09-27

Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi
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br HMG proteins mobile modulators of chromatin structure and
2024-09-27

HMG proteins: mobile modulators of chromatin structure and cellular phenotype The term “High Mobility Group” was originally coined for the HMG proteins because of their unusual solubility properties, their small size and their rapid mobility, relative to other chromatin proteins, during gel elect
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Mass spectrometry Matrix assisted laser desorption ionizatio
2024-09-27

Mass spectrometry. Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS experiment was performed in linear and positive-ion mode on a DE-STR instrument equipped with a nitrogen laser (PE Biosystems, Foster City, CA). Each spectrum was calibrated in the default mode in which 0.1%
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The habit of prescribing antibiotics just in case
2024-09-27

The habit of prescribing Tanshinone IIA---sulfonic sodium australia “just-in-case” there is an infection is based on the misguided perception that antibiotics are “safe” drugs and therefore pose little risk to patients. Surgeons need to dispel this myth. In the outpatient setting, antibiotic-associ
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br HIF Blockade in AA Therapy In lieu of the
2024-09-27

HIF-α Blockade in AA Therapy In lieu of the evidence supporting a central role for HIF-α signaling in tumor angiogenesis and CC pathobiology, significant efforts have focused on the discovery of small-molecule HIF-α inhibitors (for exhaustive compendia, see [28,44,45]). In brief, inhibitors vary
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Therefore a number of homoisoflavonoids may
2024-09-27

Therefore, a number of homoisoflavonoids may be designed in future that may be effective against angiogenesis for treating ocular neovascularization. As this apexbio dilution current study deals with robust molecular modeling techniques on SH-11037 (cpd 15) and related homoisoflavonoids and SH-11037
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